Table 1.
Baseline Clinical Variables and Relationship with Angiographic Collateral Grade.
| Baseline Variable | Collateral Grade | p-value* | |||||
|---|---|---|---|---|---|---|---|
| 0 (n=19) | 1 (n=53) | 2 (n=108) | 3 (n=88) | 4 (n=8) | |||
| Age (yrs), median (min-max) | 71 (61-81) | 64 (33-83) | 68 (23-83) | 69 (24-82) | 64 (43-78) | 0.2790 | |
| Sex, no. (%) | Female | 11 (58) | 23 (43) | 63 (58) | 49 (56) | 3 (38) | 0.3678 |
| Male | 8 (42) | 30 (57) | 45 (42) | 39 (44) | 5 (63) | ||
| Ethnic group, no. (%) | Hispanic or Latino | 1 (5) | 2 (4) | 2 (2) | 1 (1) | 0 (0) | 0.3562 |
|
Not Hispanic/Not
Latino |
17 (89) | 51 (96) | 104 (96) | 82 (93) | 8 (100) | ||
| Unknown | 1 (5) | 0 (0) | 2 (2) | 5 (6) | 0 (0) | ||
| Race, no. (%) | Asian | 0 (0) | 1 (2) | 1 (1) | 3 (3) | 0 (0) | 0.4139 |
|
Black/African
American/African Canadian |
3 (16) | 7 (13) | 18 (17) | 7 (8) | 0 (0) | ||
|
Native
Hawaiian/Other Pacific Islander |
0 (0) | 2 (4) | 0 (0) | 0 (0) | 0 (0) | ||
| Other | 0 (0) | 0 (0) | 1 (1) | 3 (3) | 0 (0) | ||
| White | 16 (84) | 43 (82) | 88 (82) | 75 (86) | 8 (100) | ||
| Atrial fibrillation, no. (%) | 9 (47) | 16 (30) | 44 (41) | 33 (38) | 2 (25) | 0.5742 | |
| History of congestive heart failure, no. (%) | 2 (11) | 11 (21) | 11 (10) | 4 (5) | 1 (13) | 0.0411 | |
| History of coronary artery disease, no. (%) | 4 (21) | 14 (26) | 20 (19) | 22 (25) | 1 (13) | 0.7237 | |
| History of diabetes, no. (%) | 3 (16) | 11 (21) | 27 (25) | 18 (20) | 2 (25) | 0.8837 | |
| History of hyperlipidemia, no. (%) | 7 (37) | 29 (55) | 49 (45) | 40 (45) | 3 (38) | 0.6538 | |
| History of hypertension, no. (%) | 19 (100) | 45 (85) | 85 (79) | 55 (63) | 6 (75) | 0.0008 | |
| Current antiplatelet use, no. (%) | 7 (37) | 25 (47) | 40 (37) | 38 (43) | 4 (50) | 0.7086 | |
| Current statin use, no. (%) | 7 (37) | 20 (38) | 41 (38) | 28 (32) | 2 (25) | 0.8742 | |
|
Modified Rankin
scale score, no. (%) |
No symptoms at all | 17 (89) | 46 (87) | 97 (90) | 79 (90) | 6 (75) | 0.5682 |
|
No significant
disability despite symptoms |
1 (5) | 5 (9) | 9 (8) | 5 (6) | 2 (25) | ||
| Slight disability | 1 (5) | 2 (4) | 2 (2) | 4 (4) | 0 (0) | ||
|
Systolic blood pressure† (mm Hg), mean
(SD) |
156.4 (21.5) |
147.7 (21.4) |
147 (20.6) | 144.1 (20.7) | 141.7 (27.6) |
0.2803 | |
| Serum glucose† (mmol/liter), mean (SD) | 7.4 (3.5) | 7.5 (3.3) | 7.2 (2.6) | 7.1 (2.6) | 7.8 (3.9) | 0.9790 | |
|
International normalized ratio†, median
(min-max) |
1 (0.9-1.6) | 1 (0.9-1.4) | 1 (0.9-1.7) | 1 (0.9-1.5) | 1.1 (0.9- 1.5) |
0.1545 | |
| NIHSS, no. (%) | NIHSS≤19 | 11 (58) | 31 (58) | 77 (72) | 64 (73) | 6 (75) | 0.3169 |
| NIHSS≥20 | 8 (42) | 22 (42) | 31 (29) | 24 (27) | 2 (25) | ||
|
Presumptive
location of stroke, no. (%) |
Brainstem / cerebellum | 0 (0) | 0 (0) | 1 (1) | 1 (1) | 0 (0) | 0.6351 |
| Left hemisphere | 7 (37) | 26 (49) | 59 (55) | 43 (49) | 2 (25) | ||
| Right hemisphere | 12 (63) | 27 (51) | 48 (44) | 43 (49) | 6 (75) | ||
| Unknown/multiple | 0 (0) | 0 (0) | 0 (0) | 1 (1) | 0 (0) | ||
| ASPECTS† no. (%) | ASPECTS 0-7 | 11 (58) | 32 (60) | 48 (44) | 37 (42) | 2 (25) | 0.1525 |
| ASPECTS 8-10 | 8 (42) | 21 (40) | 57 (53) | 49 (56) | 6 (75) | ||
|
Time from stroke onset to start of IV t-PA
(min), mean (SD) |
146.9 (26.3) |
113.2 (35.8) |
125.5 (30.7) |
121.2 (36.3) | 124 (30.4) | 0.0039 | |
*
Fisher’s Exact Test used for categorical variables, Kruskal-Wallis test used for continuous variables
†
5 subjects missing ASPECTS, 3 missing INR, 1 missing glucose, 6 missing SBP