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. 2013 Jan 10;24(5):1361–1372. doi: 10.1093/cercor/bhs421

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© The Author 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 2. — Connection of the choroid plexus with components of the forebrain hem system. (A) Schematic of the medial view of an E11.5 hemi-forebrain showing the position of the forebrain hem system (yellow), encircling the choroid plexus (cp; green). The dashed line (A and C) corresponds to the diencephalic midline that was bisected for the hemi-forebrain preparation (B). Whole mount in situ hybridization of an E12.5 hemi-forebrain reveals Wnt2b expression, specific to the cortical hem (purple), and AP2α expression, specific to the thalamic eminence (asterisk; brown). (C) Lhx1 is expressed in the E11.5 septum and thalamic eminence (asterisk) and also weakly in the cortical hem. (D) Lateral view of a single hemisphere in 3-D model of E12.5 brain showing the location of the septum (yellow), hem (red), and thalamic eminence (blue), encircling the choroid plexus (green). (E) E12.5 mouse brain sections processed for marker Ttr show the presence of the choroid plexus adjacent to both the lateral ventricles and the third ventricle. (F–H) Human sections immunostained by calbindin antibody show the development of choroid plexus from 7 to 10/11 GWs. (H) An oblique section of 10/11-GW human brain that shows the connection of choroid plexus with both the septum and cortical hem (open arrowheads), as also depicted in I. cp, choroid plexus; h, hem; s, septum; TE, thalamic eminence; III V, third ventricle. Scale bar: 200 µm (B and C).