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. 2013 Dec 9;16(Suppl 2):S76–S87. doi: 10.1093/ntr/ntt195

Table 1.

Summary of Illustrative Designs and Analyses

Illustrative design and
analysis
Treatment of time Example content/research question
Between-subjects differences Time is not represented in the analysis, though observations may be selected by time Whether more dependent smokers experience more intense craving
Contrasting events (case–control) Contrasts observations collected at different “times”—that is, in different situations—but without respect to their temporal ordering Whether the probability of drinking differs between when the person is smoking versus not smoking
Event rates: Events/unit time Uses time to calculate a rate of events (e.g., smoking) per unit of time Whether smoking rate increases when smokers are feeling restless
Sequence of events Uses time to establish a temporal ordering of events Whether negative affect is higher at the time of a lapse than during a prior, randomly selected, occasion
Clock and calendar time Time is represented conventionally, as a time of day or day of week Whether smoking rate varies by time of day
Time defined by event Time is defined by a contrast of before versus after an event Whether self-efficacy drops after a lapse, compared to its level before the lapse
Time following an anchoring event Data are analyzed for trends over time, running forward from a key event How craving intensity changes after a smoker establishes abstinence
Time preceding an anchoring event Data are analyzed for trends over time, preceding and leading up to a key event Whether negative affect is on the rise in the time leading up to a lapse
Time-to-event analyses: Time as risk The analysis focuses on the time elapsed until a certain event occurs (if it occurs at all), with shorter times indicating a greater risk per unit time Whether smokers who are more demoralized after a lapse progress more quickly to a second lapse
Events recurring over time Analyzes time-to-events, as above, but allows for multiple cycles of event recurrence How the time between one lapse to the next changes across a sequence of lapses
Change in effects over time Analyzes whether the relationship between two variables changes over time How the relationship between self-efficacy and craving changes over time