Figure 6.
The effect of siRNA (“MORD2”) on striatal MOP-r mRNA levels and density is shown in Fig 6. A. Striatal MOP-r mRNA levels in mice infused with siRNA were significantly lower than those of the controls 1 day after infusions (see also a photomicrograph from a representative mouse in 6E). B. Infusions of siRNA into the mouse striatum did not change the MOP-r mRNA levels 7 day after infusions (see also a photomicrograph from a representative mouse in 6F). C. There was not significant difference between the two groups in striatal MOP-r density at day 1 after infusions (see also a photomicrograph from a representative mouse in 6G). D. Striatal MOP-r receptor density levels were significantly lowered in siRNA (“MORD2”) groups than that of the controls (see also a photomicrograph from a representative mouse in 6H).