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. 2014 Mar 25;9:74. doi: 10.1186/1746-1596-9-74

Table 3.

Meta-analysis of the TNF-α gene polymorphisms on prostate cancer risk

Comparison
 Population
 No. of studies
 Test of association
  
 Test of heterogeneity
      OR 95% CI P value model X2 I2(%) P value
TNF-α-308G/A
  
  
  
  
  
  
  
  
AA vs. GG
 Overall
 14
 0.936
 0.733-1.195
 0.595
 F
 16.20
 19.8
 0.238
 
 Caucasia
 8
 0.762
 0.569-1.021
 0.068
 F
 5.68
 0.0
 0.461
 
 Asia
 3
 1.558
 0.620-3.419
 0.346
 F
 4.29
 30.1
 0.231
 
 Mix
 2
 1.616
 0.917-2.848
 0.097
 F
 0.11
 0.0
 0.736
 
 African-American
 1
 1.119
 0.181-6.903
 0.904
 -
 -
 -
 -
 
 PB
 5
 0.886
 0.660-1.190
 0.422
 F
 6.72
 40.5
 0.152
 
 HB
 7
 0.924
 0.557-1.481
 0.743
 F
 6.76
 11.2
 0.344
 
 HV
 2
 2.861
 0.732-11.181
 0.131
 F
 0.00
 0.0
 0.979
AG vs. GG
 Overall
 14
 1.105
 0.932-1.309
 0.251
 R
 41.38
 68.6
 <0.001
 
 Caucasia
 7
 1.234
 0.965-1.600
 0.092
 R
 31.63
 81.0
 <0.001
 
 Asia
 4
 0.928
 0.699-1.234
 0.608
 F
 4.12
 27.2
 0.249
 
 Mix
 2
 1.065
 0.882-1.288
 0.512
 F
 0.70
 0.0
 0.404
 
 African-American
 1
 0.458
 0.204-1.027
 0.058
 -
 -
 -
 -
 
 PB
 5
 0.997
 0.899-1.106
 0.958
 F
 3.39
 0.0
 0.495
 
 HB
 7
 1.174
 0.709-1.746
 0.428
 R
 32.78
 81.7
 <0.001
 
 HV
 2
 1.477
 1.047-2.085
 0.026
 F
 0.27
 0.0
 0.602
AA + AG vs. GG
 Overall
 14
 1.103
 0.932-1.306
 0.254
 R
 43.71
 70.3
 <0.001
 
 Caucasia
 8
 1.206
 0.941-1.545
 0.138
 R
 32.21
 81.4
 <0.001
 
 Asia
 3
 1.008
 0.657-1.547
 0.97
 R
 6.83
 56.1
 0.078
 
 Mix
 2
 1.101
 0.916-1.323
 0.304
 F
 0.63
 0.0
 0.429
 
 African-American
 1
 0.513
 0.242-1.088
 0.082
 -
 -
 -
 -
 
 PB
 5
 0.987
 0.892-1.091
 0.799
 F
 4.96
 19.4
 0.291
 
 HB
 7
 1.174
 0.803-1.719
 0.408
 R
 32.22
 81.4
 <0.001
 
 HV
 2
 1.531
 1.093-2.145
 0.013
 F
 0.24
 0.0
 0.628
AA vs. GG + AG
 Overall
 14
 0.92
 0.721-1.172
 0.502
 F
 16.2
 19.7
 0.239
 
 Caucasia
 7
 0.748
 0.559-1.001
 0.051
 F
 5.93
 0.0
 0.431
 
 Asia
 4
 1.559
 0.618-3.935
 0.347
 F
 3.98
 24.7
 0.263
 
 Mix
 2
 1.569
 0.893-2.757
 0.117
 F
 0.19
 0.0
 0.660
 
 African-American
 1
 1.303
 0.212-7.991
 0.775
 -
 -
 -
 -
 
 PB
 5
 0.883
 0.659-1.184
 0.407
 F
 6.26
 36.1
 0.181
 
 HB
 7
 0.886
 0.555-1.413
 0.611
 F
 7.49
 19.9
 0.278
 
 HV
 2
 2.65
 0.679-10.341
 0.161
 F
 0.00
 0.0
 0.997
TNF-α-238G/A
  
  
  
  
  
  
  
  
AA vs. GG
 Overall
 4
 1.09
 0.403-2.943
 0.866
 F
 4.61
 34.9
 0.203
 
 Caucasia
 3
 1.29
 0.436-3.816
 0.645
 F
 4.35
 54.1
 0.113
 
 African-American
 1
 0.391
 0.018-8.288
 0.547
 -
 -
 -
 -
 
 HB
 3
 1.579
 0.492-5.071
 0.442
 F
 3.750
 46.7
 0.153
 
 PB
 1
 0.344
 0.036-3.310
 0.355
 -
 -
 -
 -
AG vs. GG
 Overall
 5
 1.07
 0.680-1.683
 0.77
 R
 12.49
 68.0
 0.014
 
 Caucasia
 3
 1.284
 0.841-2.025
 0.282
 R
 5.99
 66.6
 0.050
 
 Asia
 1
 0.431
 0.200-0.931
 0.032
 -
 -
 -
 -
 
 African-American
 1
 1.179
 0.408-3.405
 0.706
 -
 -
 -
 -
 
 HB
 4
 1.008
 0.506-2.010
 0.981
 R
 11.3
 73.4
 0.01
 
 PB
 1
 1.248
 0.944-1.649
 0.12
 -
 -
 -
 -
AA + AG vs. GG
 Overall
 5
 1.06
 0.713-1.575
 0.774
 R
 9.95
 59.8
 0.041
 
 Caucasia
 3
 1.226
 0.982-1.531
 0.072
 F
 3.33
 39.9
 0.189
 
 Asia
 1
 0.431
 0.200-0.931
 0.032
 -
 -
 -
 -
 
 African-American
 1
 0.983
 0.351-2.752
 0.974
 -
 -
 -
 -
 
 HB
 4
 0.984
 0.535-1.808
 0.958
 R
 9.170
 67.3
 0.027
 
 PB
 1
 1.221
 0.926-1.610
 0.156
 -
 -
 -
 -
AA vs. GG + AG
 Overall
 4
 1.036
 0.388-2.767
 0.943
 F
 4.9
 38.2
 0.182
 
 Caucasia
 3
 0.892
 0.084-9.494
 0.925
 R
 4.63
 56.8
 0.099
 
 African-American
 1
 0.386
 0.018-8.161
 0.541
 -
 -
 -
 -
 
 HB
 3
 1.468
 0.467-4.615
 0.511
 F
 4.050
 50.6
 0.132
  PB 1 0.336 0.035-3.238 0.346 - - - -