Table 2:
Single-Nucleotide Polymorphism Analysis for Association with PGD
| rs Number | Gene | Gene Function/Disease Association | Location | Minor Allele | Risk Allele | MAF PGD | MAF Non-PGD | Odds Ratio (95% Confidence Interval) | P Value |
|---|---|---|---|---|---|---|---|---|---|
| rs2996044 | TBC1D1 | Cell growth and differentiation/obesity | Intron | C | T | 0.26 | 0.40 | 0.5 (0.4–0.7) | 3.0 × 10−5 |
| rs13283456 | PTGES2 | Prostaglandin E2 synthesis | Coding | T | T | 0.21 | 0.16 | 2.0 (1.4–2.9) | 9.3 × 10−5 |
| rs2925956 | TBC1D1 | Cell growth and differentiation/obesity | Intron | A | G | 0.31 | 0.41 | 0.6 (0.4–0.8) | 1.2 × 10−4 |
| rs13132184 | TBC1D1 | Cell growth and differentiation/obesity | Intron | C | T | 0.10 | 0.21 | 0.5 (0.3–0.7) | 1.6 × 10−4 |
| rs7973796 | PMCH | Hypothalamic neurotransmitter/obesity | 5′ UTR | G | A | 0.40 | 0.54 | 0.6 (0.5–0.8) | 1.7 × 10−4 |
| rs3024388 | F13A1 | Coagulation cascade/venous thrombosis | Intron | T | T | 0.30 | 0.20 | 1.8 (1.3–2.5) | 2.0 × 10−4 |
| rs12452616 | GAA | Glycogen degradation | Intron | A | A | 0.27 | 0.20 | 1.8 (1.3–2.5) | 2.1 × 10−4 |
| rs11957406 | PTGER4 | Prostaglandin E receptor (EP4) | Intron | A | A | 0.56 | 0.47 | 1.7 (1.3–2.3) | 2.2 × 10−4 |
| rs237865 | CAV3 | Muscle development | 5′ UTR | C | C | 0.51 | 0.40 | 1.7 (1.3–2.2) | 2.4 × 10−4 |
| rs17588591 | COL4A1 | Extracellular matrix/punctate palmoplantar keratoderma | Intron | G | G | 0.37 | 0.29 | 1.7 (1.3–2.3) | 2.6 × 10−4 |
| rs16836965 | CASP8 | Cell death and tumor regulation | Intron | T | T | 0.08 | 0.02 | 3.2 (1.7–6.0) | 2.7 × 10−4 |
| rs4434423 | PTGER4 | Prostaglandin E receptor (EP4) | 5′ UTR | T | A | 0.31 | 0.42 | 0.6 (0.4–0.8) | 2.8 × 10−4 |
| rs260400 | IRX4 | Ventricular differentiation and cardiac development | 5′ UTR | A | A | 0.15 | 0.09 | 2.1 (1.4–3.1) | 3.1 × 10−4 |
| rs3772843 | ITGB5 | Cell adhesion | Intron | A | A | 0.23 | 0.14 | 1.9 (1.3–2.6) | 3.2 × 10−4 |
| rs1881597 | PRKG1 | Platelet aggregation | 3′ UTR | T | C | 0.20 | 0.31 | 0.6 (0.4–0.8) | 3.8 × 10−4 |
| rs4133101 | PTGER4 | Prostaglandin E receptor (EP4) | 5′ UTR | A | G | 0.32 | 0.42 | 0.6 (0.5–0.8) | 4.8 × 10−4 |
| rs17004504 | FTCD | Folate metabolism/autoimmune hepatitis | Intron | T | T | 0.08 | 0.03 | 2.9 (1.6–5.2) | 4.8 × 10−4 |
Definition of abbreviations: MAF = minor allele frequency; PGD = primary graft dysfunction; UTR = untranslated region.
Odds ratio and P value are based on an additive model. Analysis is corrected for first two principle components derived from ancestry informative markers, cardiopulmonary bypass use, and preoperative lung disease.