Table 1:
Demographics and Comorbidities Associated with Clinical Outcomes in Bronchiectasis
| N | 4-yr Mortality Rate | Hospitalizations | Annual Exacerbation Frequency | SGRQ | |
|---|---|---|---|---|---|
| Age, yr | |||||
| <30 (ref) | 17 | 0 (0%) | 2 (11.8%) | 1.56 (1.4) | 26.0 (22.2) |
| 30–49 | 50 | 1 (2%) | 11 (22.0%) | 1.74 (1.4) | 41.4 (21.6) |
| 50–69 | 268 | 11 (4.1%) | 82 (30.6%) | 1.94 (1.4) | 42.3 (23.9) |
| 70–79 | 203 | 29 (14.3%) | 64 (31.5%) | 1.78 (1.4) | 45.8 (22.8) |
| 80+ | 68 | 22 (32.4%) | 30 (44.1%) | 1.73 (1.2) | 46.5 (22.1) |
| P value | <0.0001 | 0.03 | 0.5 | 0.008 | |
| Sex | |||||
| Male (ref) | 243 | 29 (11.9%) | 73 (30.0%) | 1.85 (1.42) | 42.2 (24.0) |
| Female | 365 | 33 (9.0%) | 116 (31.8%) | 1.82 (1.32) | 44.0 (22.7) |
| P value | 0.2 | 0.6 | 0.8 | 0.4 | |
| BMI | |||||
| <18.5 | 42 | 13 (31.0%) | 22 (52.4%) | 2.44 (1.9) | 47.5 (27.4) |
| 18.5–25 (ref) | 227 | 21 (9.1%) | 71 (30.9%) | 1.84 (1.3) | 40.8 (22.2) |
| 25–30 | 214 | 15 (7.0%) | 55 (25.7%) | 1.62 (1.2) | 40.2 (21.7) |
| 30+ | 125 | 13 (10.4%) | 41 (32.8%) | 1.93 (1.5) | 50.7 (24.8) |
| P value | <0.0001 | 0.008 | 0.003 | <0.0001 | |
| Underlying cause | |||||
| Idiopathic/postinfective (ref) | 386 | 39 (10.1%) | 110 (28.5%) | 1.89 (1.4) | 42.0 (23.3) |
| Previous TB | 82 | 11 (13.4%) | 33 (40.2%) | 1.50 (1.0) | 41.8 (25.6) |
| Previous ABPA | 49 | 3 (6.1%) | 20 (40.8%) | 1.64 (1.1) | 45.8 (18.4) |
| Rheumatoid arthritis | 44 | 5 (11.4%) | 13 (29.5%) | 1.98 (1.6) | 46.8 (23.0) |
| Inflammatory bowel disease | 14 | 2 (14.3%) | 6 (42.9%) | 1.70 (1.4) | 54.3 (19.5) |
| Others | 33 | 2 (6.1%) | 7 (21.2%) | 2.11 (1.7) | 49.6 (24.0) |
| P value | 0.7 | 0.1 | 0.1 | 0.1 | |
| Comorbidities | |||||
| Chronic cardiac disease | 139 | 27 (19.4%)* | 41 (29.5%) | 1.70 (1.3) | 46.1 (22.4) |
| Cerebrovascular disease | 63 | 16 (25.4%) | 35 (55.6%)* | 1.73 (1.4) | 48.0 (23.1) |
| Chronic renal failure | 36 | 6 (16.7%) | 14 (38.9%) | 1.40 (1.1) | 44.3 (21.2) |
| Diabetes mellitus | 67 | 6 (9.0%) | 13 (19.4%) | 1.81 (1.3) | 44.9 (23.6) |
| Current smokers | 42 | 4 (9.5%) | 18 (42.9%) | 2.12 (1.5) | 42.4 (20.4) |
Definition of abbreviations: ABPA = allergic bronchopulmonary aspergillosis; BMI = body mass index; ref = reference; SGRQ = St. George's Respiratory Questionnaire; TB = tuberculosis.
P values refer to comparisons between groups using chi-squared test (categorical data) or analysis of variance (continuous data).
*
P < 0.05, comparisons made with patients without this comorbidity. All other relationships not statistically significant.