Figure 5.

The sensitivity of the derivative, SK, of ΔG_el with respect to the logarithm of the 1:1 salt concentration computed at 0.1 M salt concentration as a function of the different parameters of the model for the DNA-drug complexes in this study. (a) SK computed with the uniform ion size SMPBE as a function of the ion size. (b) SK computed with the NLPBE as a function of the thickness of the Stern layer. (c) SK computed with the NLPBE and the solvent accessible surface (SAS) as a function of the size of the probe used to define the SAS. (d) SK computed with the NLPBE as a function of the internal dielectric constant. All figures except (c) were created using the solvent-excluded surface rather than the SAS.