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. 2014 Apr 7;9(4):e93164. doi: 10.1371/journal.pone.0093164

Figure 5. The expression pattern of LRIG1 and EGFR.

Figure 5

The expression pattern of LRIG1 (A–C, G–I) and EGFR (D–F, J–L) in case 1 (A, D), case 2 (B, E), case 3 (C, F), case 4 (G, J), case 5 (H, K), and case 6 (I, L). The expression pattern in conjunctivas (a, d), limbus (b, e), and corneas (c, f) in healthy controls are also presented. In benign cases, LRIG1 was overexpressed throughout the layers (A–C). In case 3, koilocytes seemed to be negative for LRIG1 (C). On the other hand, it was generally negative in malignant cases (G–I). Only a small number of LRIG1 positive cells were found in the very surface layer of malignant cases (G–I). On the contrary, EGFR expression was faint in benign cases (D–F), and inversely very strong in malignant cases (J–L). Scale bars = 100 µm.