Table 1. Nasal polyp tissue (n = 9) was incubated with FF or MF at different concentrations for 1 hour and subsequently stimulated with SEB for 24 hours (pre-challenge incubation).
| Cytokine | Fluticasone furoate | p- value for max. inhibition | Mometasone furoate | ||||
| Max. inhibition (median (Interquartile range) in % | Concentr. of max. inhibition | Lowest concentr. with significant inhibition | Max. inhibition (median (Interquartile range) in % | Concentr. of max. inhibition | Lowest concentr. with significant inhibition | ||
| IFN-γ | 66 (56.5–77.5) | 10−8 M | 10−10 M | P = 0.7040 | 69 (62.8–78.) | 10−8 M | 10−9 M |
| IL-2 | 67.5 (52–75.6) | 10−8 M | 10−10 M | P = 0.7223 | 75 (46.5–79) | 10−8 M | 10−9 M |
| IL-5 | 81.5 (72–88) | 10−8 M | 10−11 M | P = 0.3606 | 89 (80.5–91) | 10−8 M | 10−10 M |
| IL-17 | 76 (68–82.5) | 10−9 M | 10−10 M | P = 0.7223 | 77 (65.8–79) | 10−8 M | 10−9 M |
| TNF-α | 65.5 (46–75.5) | 10−8 M | 10−10 M | P = 0.2008 | 42 (32.5–69) | 10−8 M | 10−9 M |
There was no significant difference in the maximal inhibition of cytokine release over 24 h; however, FF induced a comparable inhibition for all cytokines at lower molar concentrations.