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. 2014 Apr 7;9(4):e93743. doi: 10.1371/journal.pone.0093743

Figure 1. Effect of relaxin on blood pressure, urinary albumin excretion, and survival.

Figure 1

(A) Systolic blood pressure increased progressively in vehicle-treated dTGR from week 5 to week 7. Relaxin treatment had no influence on blood pressure; SD rats were normotensive. (B) Vehicle-treated dTGR showed significantly increased 24-hour urinary albumin excretion compared with control values. Relaxin did not eliminate the development of albuminuria in dTGR. (C) Kaplan-Meier survival analysis of vehicle-treated dTGR and dTGR rats receiving low and high dose relaxin. By week 7, half of untreated dTGR were dead. Relaxin did not improve survival of the dTGR. No controls died before end of study (data not shown).