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. 2014 Mar 27;4:16. doi: 10.1186/2045-3701-4-16

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Copyright © 2014 Cook et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Mitochondria directly donate membrane material to form autophagosomes. Electron micrograph images of A. vehicle treated LCC9 breast cancer cells. B. LCC9 cells treated with 100 nM fulvestrant for 72 hours. C. LCC9 cells transfected with estrogen receptor-α shRNA. D. LCC9 cells treated with 10 μM Imatinib for 72 hours. M indicates mitochondria; Av indicates an autophagic vesicle; * indicates mitochondria-autophagosome interaction.