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Mitophagy in human breast cancer cells. A. EM image of MCF7 cells treated with MKT-077, a cationic drug that concentrates in the mitochondria and inhibits glucose-regulated protein 75. Image indicates that mitochondria forming autophagosomes occur in other cell lines. B. EM image of LCC9 cells treated with ICI. Image shows an example of classical mitophagy where a mitochondria is engulfed by an autophagosome.
