Table 1. Dia binding partners and their proposed functions.

binding partner	binding domain	physiological function	biochemical function	references
Rho1/RhoA	RBD	activation of nucleation and elongation	release of autoinhibition	13 , 16 , 19 , 41 , 63 , 110
IpgB2	RBD			158
PIP2, phospholipids	N-basic	apical/membrane localizaton		47 - 49 , 158 , 161
Profilin	FH1		required for elongation activity	17 - 19
Cip4/Toca/FBP17	FH1	antagonises Dia mediated membrane stabilization and cytokinesis	inhibition of nucleation and elongation	22
IRSp53	FH1	filapodia induction		24 , 81 , 162
DIP/Wish	FH1	blebbing in amoeboid migratory cells	mDia2 dependent filament assembly and bundling	23 , 25 , 163 - 165
RAGE	FH1	cell migration		28 , 166
Ena/Vasp	FH2	lamellipodia, SRF activity		34 , 36 , 37
Clip-170	FH2	phagocytosis		35
Neurochondrin	FH3	unknown		45
Abi	DD	junctions in MDCK cells		44
Liprin	DID-DD	antagonises membrane localizaton		42
Anillin	DID	cytokinesis, localization of mDia2		43
IQGAP	DID	phagocytosis, caveolae membrane insertion		46 , 167
APC	DAD		synergistic actin polymerization	51 - 53 , 64
INF2	DAD	lamellipodia in podocyte	actin polymerization and SRF activation	56 , 168
Fli-I	DAD		promotes release of Dia autoinhition	54
Hck		neutrophil chemotaxis		148
HDAC6		MT deacetylation		169
PKD2	N-terminal	spindle localization of PKD2		73
Exportin 6		nuclear export		170
Importin-a	N-terminal	nuclear import		171
Crm1	C-terminal	nuclear export		171