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. Author manuscript; available in PMC: 2014 Apr 7.
Published in final edited form as: Toxicol Pathol. 2013 Apr 2;42(2):376–385. doi: 10.1177/0192623313483213

Figure 2.

Figure 2

ABR threshold shifts. (A) Shift of the frequency average after a single furosemide injection. The shift was largest (approximately 53 dB) 30 min after furosemide application (the earliest time tested) and recovered at 12 hr. (B) Threshold shift audiogram 7 days after consecutive cisplatin injections (3 mg/kg × 5 d). The shift was biased to high frequencies (up to 50 dB) and was lower at lower frequencies (around 30 dB). (C) Threshold shift audiogram 7 days after coadministration of 200 mg/kg furosemide and various Cis doses. Cis was administered 30 min after furosemide. (D) Threshold shift audiogram 7 days after coadministration of 0.2 mg/kg Cis and 200 mg/kg furosemide at various intervals. The threshold shift was nearly zero at a zero interval and higher at longer intervals.