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. 2014 Apr 7;9(4):e94079. doi: 10.1371/journal.pone.0094079

Figure 5. The effect of the combination treatment on key pro-survival kinases.

Figure 5

The combination of taxol and shikonin inhibites the activation of Akt (A), p70S6 (B), and ERKs (C). Human phosphor-kinase array analysis was performed following the manufacturer's instruction. Whole cell lysate from MB231 cells treated with DMSO, taxol (8 nM), shikonin (2.5 μM), or the combination. The normalized intensity for each antibody was plotted. * p<0.05 when compared to the control (DMSO); # p<0.05 when compared to the combination.