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. 2014 Apr 7;9(4):e94032. doi: 10.1371/journal.pone.0094032

Figure 5. Time course of the MuRF1-hiLUCs reporter induction during a 14-day HLU study.

Figure 5

MuRF1-hiLUCs reporter rats (n = 8) were hindlimb unloaded (HLU) for 14 days. In vivo images of the ventral, right lateral and dorsal views of the rats were acquired before the unloading (baseline) and every other day thereafter from day 1 to day 14. (A) Ventral, lateral and dorsal images of a representative HLU rat throughout the time course of the unloading. (B) ROIs from all three views were used to quantify the fold induction of the MuRF1-hiLUCs reporter during the time course of the unloading (n = 8). Fold inductions of the luminescent intensities were calculated over baseline values. Data are presented as means (symbols) + SEM (lines). Statistics were performed using ordinary two-way ANOVA with Dunnett's multiple comparisons test. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.