Table 1. Known cancer genes have extreme S-scores.

	GBM	OV	BR	CR
Real Set	19	54	56	22
10,000 Simulated Sets	8.08 (2.49–13.66)	34.07(23.76–44.38)	23.07(14.27–31.87)	9.15(3.19–15.11)
p-value	0.0002	0.0001	<0.0001	0.0001

Number of genes (Real Set) with S-score >2 or <−2 in the 138 cancer gene list from Volgestein et al. [1]. Numbers in the “10,000 Simulated Sets” row correspond to average number of genes with S-score >2 or <−2 in 10,000 sets containing 138 genes randomly selected. Between parentheses is the interval corresponding to the average +/− 2× standard deviation. P-value of the difference between real and simulated sets is shown in the last row.