Table 3.
Comparison of patients with thyroid medication for TSH levels exceeding the threshold of 2.5 μIU/ml and patients without any thyroid medication
| |
Thyroid medication for TSH levels |
No thyroid medication |
Thyroid medication for overt hypothyroidism |
p
d
|
p
e
|
|---|---|---|---|---|---|
| > 2.5 μIU/ml (n = 71) | (n = 372) | (n = 97) | |||
|
Age (years)
a
|
33 (27-40) |
33 (28-39) |
34 (30-39) |
0.324 |
0.047
c
|
|
Body mass index (kg/m
2
)
a
|
22.3 (19.4-25.1) |
22.9 (20.3-26.7) |
23.1 (21.4—25.1) |
0.260 |
0.340 |
|
Primary infertility (vs. secondary infertility)
b
|
36 (50.7) |
202 (54.3) |
39 (40.2) |
0.578 |
0.176 |
|
Parity
b
|
0 (0-1) |
0 (0-1) |
0 (0-1) |
0.961 |
0.667 |
|
TSH (μIU/ml)
a
|
1.6 (1.1-2.2) |
1.5 (1.1-2.0) |
1.4 (0.4-2.2) |
0.422 |
0.107 |
|
TPO-Ab > upper level of normal
b
|
8 (11.3) |
14 (3.8) |
39 (40.2) |
0.014
c
|
< 0.001
c
|
|
TG-Ab > upper level of normal
b
|
22 (31.0) |
57 (15.3) |
28 (28.9) |
0.004
c
|
0.767 |
|
Presence of PCO-S
b
|
16 (22.5) |
56 (15.1) |
17 (17.5) |
< 0.001
c
|
0.419 |
|
Metformin treatment
b
|
5 (7.0) |
19 (5.1) |
10 (10.3) |
0.565 |
0.588 |
|
Clomifen citrate stimulation
b
|
23 (32.4) |
115 (30.9) |
27 (27.8) |
0.805 |
0.523 |
|
Number of IUI treatment cycle
a
|
1 (1-1) |
1 (1-1) |
1 (1-1) |
0.063 |
0.598 |
|
Ovulation induction with HCG
b
|
36 (50.7) |
181 (48.7) |
49 (50.5) |
0.752 |
0.981 |
|
Endometrial thickness
a
|
9 (8-10) |
9 (8-10) |
9 (8-10) |
0.866 |
0.864 |
|
Male factor
b
|
35 (49.3) |
195 (52.4) |
52 (53.6) |
0.629 |
0.581 |
| Pregnancy rate b | 16 (23.9) | 19 (5.1) | 2 (2.1) | < 0.001 c | < 0.001 c |
Patients with overt hypothyroidism were excluded for this analysis.
aContinuous variable, provided in median (interquartile range).
bNominal variable, provided in n (%).
cItalic letters indicate statistical significance.
dComparison of patients with thyroid medication for TSH levels > 2.5 μIU/ml and patients without thyroid medication.
eComparison of patients with thyroid medication for TSH levels > 2.5 μIU/ml and patients with thyroid medication for overt hypothyroidism.