Table 4. Predictors of in-hospital mortality (training sample).

Univariate analysis				Multivariate analysis—parameters included in the Royal Free Hospital score
	OR	95% CI	P	OR	95% CI	P
Indication
Sepsis	1.199	0.780–1.843	0.407
Variceal bleeding	0.290	0.200–0.422	<0.0005	0.369	0.222–0.615	<0.0005
Other
Sodium	0.977	0.961–0.994	0.008
Creatinine	1.003	0.1.001–1.004	<0.0005
Urea	1.048	1.028–1.096	<0.0005	1.036	1.010–1.064	0.007
Bilirubin	1.005	1.004–1.007	<0.0005	1.003	1.001–1.005	0.002
White blood cells	1.043	1.020–1.067	<0.0005
Platelets	0.997	0.995–0.999	0.007
INR	2.135	1.73–2.634	<0.0005	1.431	1.063–1.926	0.018
Lactate	1.250	1.168–1.339	<0.0005	1.145	1.040–1.260	0.006
PH	0.016	0.04–0.64	<0.0005
PaCO2	1.172	1.034–1.328	0.013
FiO2	11.939	5.045–28.256	<0.0005
PaO2/FiO2	0.997	0.996–0.999	<0.0005
A-a gradient	1.004	1.002–1.005	<0.0005	1.004	1.002–1.006	<0.0005

A-a gradient, alveolar-arterial partial pressure oxygen gradient; CI, confidence interval; INR, international normalized ratio; OR, odds ratio.