Table 6. Performance of different prognostic models in predicting mortality using the optimal cut-off point (validation set).
| Prognostic model | Cutoff point | Youden index | Sensitivity (%) | Specificity (%) | PPV | NPV | LR+ | LR− |
|---|---|---|---|---|---|---|---|---|
| RFH score | −0.82 | 0.45 | 85.7 | 59.3 | 0.71 | 0.78 | 2.1 | 0.24 |
| SOFA | 10.5 | 0.513 | 68 | 83.3 | 0.84 | 0.68 | 4.1 | 0.38 |
| MELD | 21 | 0.484 | 76.5 | 71.9 | 0.78 | 0.71 | 2.72 | 0.33 |
| APACHE II | 17.5 | 0.369 | 59.5 | 77.4 | 0.78 | 0.59 | 2.6 | 0.52 |
| MELD-sodium | 22.5 | 0.408 | 72.5 | 68.3 | 0.74 | 0.66 | 2.29 | 0.4 |
| Child-Pugh | 12.5 | 0.302 | 46.9 | 83.3 | 0.79 | 0.50 | 2.8 | 0.64 |
APACHE, Acute Physiology and Chronic Health Evaluation; LR+ likelihood ratio positive; LR−, likelihood ratio negative; MELD, Model for End-Stage Liver Disease; NPV, negative predictive value; PPV, positive predictive value; RFH, Royal Free Hospital; SOFA, Sequential Organ Failure Assessment.