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Peptide antagonism is associated with loss of tight clustering of KIR. (A) The antagonist peptide induces clustering of KIR and SHP-1 recruitment to the immune synapse. However, the clustering is diffuse and there is no inhibitory signal generated. (B) An inhibitory peptide induces tight clustering of KIR, SHP-1 recruitment, and inhibitory signaling. (C) The antagonist peptide abrogates tight clustering and thence inhibitory signaling.
