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. 2014 Mar 31;5:133. doi: 10.3389/fimmu.2014.00133

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Copyright © 2014 Cassidy, Cheent and Khakoo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model for peptide synergy. (A) A synergistic peptide induces recruitment of CD94 homodimers, but not CD94:NKG2A to the immune synapse. Therefore, there is no inhibitory signal generated. (B) At low levels of inhibitory peptide CD94:NKG2A is recruited to the immune synapse and there is inhibitory signaling. (C) The synergistic peptide augments the inhibitory signaling due to low levels of inhibitory peptide by stabilizing the immune synapse.