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. 2014 Mar 31;5:133. doi: 10.3389/fimmu.2014.00133

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Copyright © 2014 Cassidy, Cheent and Khakoo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NKG2A+ NK cells are more sensitive to changes in the cell-surface levels of MHC class I at low, as compared to high, surface levels of MHC class I. 721.174 cells were loaded with increasing concentrations of peptide and used as targets in CD107a assays. The levels of degranulation of NKG2A+ (A) or KIR2D:2/3+ (B) NK cells were plotted against levels of cognate MHC class I:peptide. In (A) HLA-E was loaded with increasing concentrations of the HLA-G leader peptide and in (B) HLA-Cw*0102 was loaded with increasing concentrations of the VAP-FA peptide. At between 10 and 20% of maximal HLA-E levels, there is an increase of ~20% in the fraction of degranulating NKG2A+ NK cells (δ_lo) but between 60 and 70% of maximal HLA-E levels, this change is less than 5% (δ_hi). For KIR+ NK cells, δ_lo and δ_hi are similar at ~10%. Data were derived from Cheent et al. (47).