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. 2014 Apr 1;8:87. doi: 10.3389/fncel.2014.00087

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Copyright © 2014 Lin, Chen, Cheng, Hu and Hsueh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enhancement of mGluR5 signaling ameliorates the behavioral defects in Sarm1 knockdown mice. CDPPB (10 mg/kg of animal body weight) or a vehicle control was intraperitonally injected into mice six hours before the behavioral assay. (A) The results of contextual fear conditioning are shown. (B) The results of reciprocal social interaction are shown. CDPPB did not obviously influence the behaviors of WT littermates. However, CDPPB rescued the defects observed in Sarm1 knockdown mice. The sample sizes (n) are indicated in the column. *P < 0.05; ns, not significant.