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. 2014 Apr 7;211(4):653–668. doi: 10.1084/jem.20130627

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© 2014 Wynosky-Dolfi et al.

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Figure 3. — Deletion of bacterial TCA genes activates the canonical NLRP3 inflammasome. (A) B6, Casp1^−/−, Casp11^−/−, and Casp1^−/−Casp11^−/− BMDMs were infected with bacterial TCA cycle mutants, and cell death was measured 4 h after infection by LDH release assay. (B and C) Supernatants from infected cells were analyzed 4 h after infection by ELISA for IL-1β (B) and IL-6 (C). LPS+ATP was used as a positive control and fliCfljB (parent strain for indicated mutants) was used as a negative control. All experiments were performed three independent times in triplicate, and data from representative experiments are shown. Error bars represent SEM. *, P < 0.05.