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. 2014 Apr 7;211(4):685–700. doi: 10.1084/jem.20131343

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© 2014 Willinger et al.

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Figure 7. — S1PR1 internalization and CD69 down-modulation are not dependent on Gαi signaling. (A) S1PR1 surface expression on mature CD4 SP thymocytes and naive CD4 T cells (n = 5). Green histograms represent background S1PR1 staining (FTY720-treated mice). (B) WT and Cd4-creRosa26^PTX/+ mice were injected i.p. with PBS or FTY720 (2 mg/kg body weight). S1PR1 surface expression on mature CD4 SP thymocytes (n = 3) was measured by flow cytometry 16 h later. Green histograms represent S1PR1 staining on DP thymocytes as negative control. (C) S1PR1 and CD69 surface expression on CD4 SP thymocytes from WT and Cd4-creRosa26^PTX/+ mice (n = 4). Results are representative of two (B and C) or three (A) experiments.