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. 2014 Apr 7;211(4):635–642. doi: 10.1084/jem.20132398

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© 2014 Male et al.

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Figure 1. — E4bp4^−/− mice, but not other NK-deficient strains, lack NKPs. (A) Flow cytometry gating strategy for identification of pre-NKP and rNKP in bone marrow from E4bp4^+/+ (top) and E4bp4^−/− (bottom) mice. Frequency of gated population is shown. (B–D) The graphs show the frequency of LMPPs, CLPs, pre-NKPs, and rNKPs as a percentage of the total lineage-negative population in bone marrow, the frequency of iNK and mNK as a percentage of the scatter gate, and absolute numbers of all NK developmental intermediates. (B) E4bp4^+/+ and E4bp4^−/−; six mice per genotype. (C) Rag^−/− and Rag^−/−Il15ra^−/−; three mice per genotype. (D) T-bet^+/+ and T-bet^−/−; three mice per genotype. Error bars show SEM. **, P < 0.005.