Skip to main content
. 2014 Jan 24;21(5):797–810. doi: 10.1038/cdd.2014.3

Figure 2.

Figure 2

GRP78 is a high-affinity cell-surface receptor for ISM and it is required for mediating ISM-induced antiangiogenesis and apoptosis. (a) Identification of ISM's binding partners in plasma membrane. (b) ISM co-IP with GRP78 from HUVECs plasma membrane fraction. (c) Determination of binding affinity between ISM and GRP78; n=3. (d) Similar with αvβ5 integrin antibodies, GRP78 antibody partially blocked ISM-mediated ECs adhesion. **P<0.01, n=3. Error bars denote S.E.M. (e) Anti-GRP78 antibody interfered with the anti-tube formation action of ISM in a dose-dependent manner. *P<0.05, n=3. Error bars denote S.E.M. (f) Anti-GRP78 antibody dose-dependently blocked ISM-induced EC apoptosis. *P<0.05, n=3. Error bars denote S.E.M.