Figure 1.

Functional anti-miR screening in NIH-H460 cells. (a) Diagram showing results of LNA library (∼900 LNAs) screening in NIH-H460 cells. The viable cell number was evaluated 72 h after transfection by Cell Titer-Glo luminescent cell viability assay and normalized to the average of all samples, excluding controls. Values above and below two fold standard deviation (red dashed lines) were considered as significant. Reported is the mean±S.E.M. of the screening performed in triplicate; each dot represents an individual LNA. (b) Table showing 10 LNAs that resulted most effective in NIH-H460 cells and relative viability