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p53 is activated on miR-197 downmodulation. (a) Unsupervised hierarchical clustering of genes belonging to ‘cell cycle' and ‘p53' pathways (listed by KEGG pathways) that are significantly modulated on miR-197 depletion; genes in the heatmap are shown starting from the most upregulated to the most downmodulated one. (b and c) p53 mRNA and protein levels on LNA-197 treatment in NIH-H460 cells. (d) Western blotting showing p53 phosphorylation at Ser15, 24 h after LNA-197 transfection
