Table 1.

P4 Medicine is Revolution in How to Practice Medicine

Reactive Medicine—Evidence-based Medicine	Proactive P4 Medicine
Reactive--respond after a patient is sick (symptoms based)	Proactive--responds before a patient is sick (based on pre-symptomatic markers)
Disease-treatment system	Wellness-maintenance system
Few measurements	Many measurements, including complete genome sequencing, high-parameter blood diagnostics, many longitudinal omics measurements
Disease-centric, with standard of care associated with a disease diagnosis	Individual-centric, with standard of care tailored more fully to multiple measurements
Records not highly linked	Deeply integrated data that can be mined for continued improvement of healthcare strategies
Large-scale diffusion of medical information mediated mostly through physicians alone	Social networking of patients to enhanced shared experiences and diffusion of knowledge in consultation with their physicians
Drugs tested against large populations—10s of thousands to develop statistics for FDA	Stratification of disease populations into small groups, 50 or so, that can be effectively treated to achieve FDA approval