Table 1.
IHC ER P-value1 |
IHC PgR P-value1 |
qPCR ER P-value1 |
qPCR PgR P-value1 |
Therapy P-value1 |
|
---|---|---|---|---|---|
I. Placebo Arm Cox Model for All Patients: All IHC values |
|||||
IHC | 0.27 | 0.08 | N/A | N/A | N/A |
Standardized IHC | 0.96 | 0.07 | N/A | N/A | N/A |
qPCR | N/A | N/A | 0.12 | 0.02 | N/A |
Standardized qPCR | N/A | N/A | 0.12 | 0.02 | N/A |
IHC and qPCR | 0.08 | 0.41 | 0.03 | 0.15 | N/A |
Standardized IHC and qPCR | 0.40 | 0.19 | 0.12 | 0.47 | N/A |
Cox Model for Patients with Positive IHC ER and/or PgR |
|||||
IHC | 0.25 | 0.29 | N/A | N/A | N/A |
Standardized IHC | 0.53 | 0.07 | N/A | N/A | N/A |
qPCR | N/A | N/A | 0.23 | 0.01 | N/A |
Standardized qPCR | N/A | N/A | 0.23 | 0.01 | N/A |
IHC and qPCR | 0.01 | 0.67 | 0.04 | 0.01 | N/A |
Standardized IHC and qPCR | 0.21 | 0.50 | 0.11 | 0.04 | N/A |
II. Tamoxifen Arm Cox Model for All Patients: All IHC values |
|||||
IHC | 0.18 | 0.61 | N/A | N/A | N/A |
Standardized IHC | 0.44 | 0.89 | N/A | N/A | N/A |
qPCR | N/A | N/A | 0.46 | 0.83 | N/A |
Standardized qPCR | N/A | N/A | 0.46 | 0.83 | N/A |
IHC and qPCR | 0.26 | 0.69 | 0.79 | 0.95 | N/A |
Standardized IHC and qPCR | 0.50 | 0.58 | 0.75 | 0.48 | N/A |
Cox Model for Patients with Positive IHC ER and/or PgR |
|||||
IHC | 0.30 | 0.57 | N/A | N/A | N/A |
Standardized IHC | 0.37 | 0.82 | N/A | N/A | N/A |
qPCR | N/A | N/A | 0.22 | 0.19 | N/A |
Standardized qPCR | N/A | N/A | 0.22 | 0.19 | N/A |
IHC and qPCR | 0.75 | 0.57 | 0.34 | 0.20 | N/A |
Standardized IHC and qPCR | 0.67 | 0.14 | 0.22 | 0.07 | N/A |
III. Both Arms Together Cox Model for All Patients: All IHC values |
|||||
IHC | 0.20 | 0.45 | N/A | N/A | 0.003 |
Standardized IHC | 0.63 | 0.21 | N/A | N/A | 0.004 |
qPCR | N/A | N/A | 0.66 | 0.20 | 0.004 |
Standardized qPCR | N/A | N/A | 0.45 | 0.19 | 0.003 |
IHC and qPCR | 0.07 | 0.75 | 0.15 | 0.48 | 0.002 |
Standardized IHC and qPCR | 0.28 | 0.22 | 0.20 | 0.99 | 0.003 |
Cox Model for Patients with Positive IHC ER and/or PgR |
|||||
IHC | 0.18 | 0.43 | N/A | N/A | 0.004 |
Standardized IHC | 0.47 | 0.05 | N/A | N/A | 0.005 |
qPCR | N/A | N/A | 0.75 | 0.30 | 0.005 |
Standardized qPCR | N/A | N/A | 0.75 | 0.30 | 0.005 |
IHC and qPCR | 0.07 | 0.75 | 0.25 | 0.53 | 0.002 |
Standardized IHC and qPCR | 0.34 | 0.10 | 0.55 | 0.97 | 0.005 |
1P-value is for factor's inclusion in stratified Cox model, with adjustment for stratification factors of nodal status and adjuvant chemotherapy.