Table 1.

NCIC CTG MA

	IHC ER P-value1	IHC PgR P-value1	qPCR ER P-value1	qPCR PgR P-value1	Therapy P-value1
I. Placebo Arm Cox Model for All Patients: All IHC values
IHC	0.27	0.08	N/A	N/A	N/A
Standardized IHC	0.96	0.07	N/A	N/A	N/A
qPCR	N/A	N/A	0.12	0.02	N/A
Standardized qPCR	N/A	N/A	0.12	0.02	N/A
IHC and qPCR	0.08	0.41	0.03	0.15	N/A
Standardized IHC and qPCR	0.40	0.19	0.12	0.47	N/A
Cox Model for Patients with Positive IHC ER and/or PgR
IHC	0.25	0.29	N/A	N/A	N/A
Standardized IHC	0.53	0.07	N/A	N/A	N/A
qPCR	N/A	N/A	0.23	0.01	N/A
Standardized qPCR	N/A	N/A	0.23	0.01	N/A
IHC and qPCR	0.01	0.67	0.04	0.01	N/A
Standardized IHC and qPCR	0.21	0.50	0.11	0.04	N/A
II. Tamoxifen Arm Cox Model for All Patients: All IHC values
IHC	0.18	0.61	N/A	N/A	N/A
Standardized IHC	0.44	0.89	N/A	N/A	N/A
qPCR	N/A	N/A	0.46	0.83	N/A
Standardized qPCR	N/A	N/A	0.46	0.83	N/A
IHC and qPCR	0.26	0.69	0.79	0.95	N/A
Standardized IHC and qPCR	0.50	0.58	0.75	0.48	N/A
Cox Model for Patients with Positive IHC ER and/or PgR
IHC	0.30	0.57	N/A	N/A	N/A
Standardized IHC	0.37	0.82	N/A	N/A	N/A
qPCR	N/A	N/A	0.22	0.19	N/A
Standardized qPCR	N/A	N/A	0.22	0.19	N/A
IHC and qPCR	0.75	0.57	0.34	0.20	N/A
Standardized IHC and qPCR	0.67	0.14	0.22	0.07	N/A
III. Both Arms Together Cox Model for All Patients: All IHC values
IHC	0.20	0.45	N/A	N/A	0.003
Standardized IHC	0.63	0.21	N/A	N/A	0.004
qPCR	N/A	N/A	0.66	0.20	0.004
Standardized qPCR	N/A	N/A	0.45	0.19	0.003
IHC and qPCR	0.07	0.75	0.15	0.48	0.002
Standardized IHC and qPCR	0.28	0.22	0.20	0.99	0.003
Cox Model for Patients with Positive IHC ER and/or PgR
IHC	0.18	0.43	N/A	N/A	0.004
Standardized IHC	0.47	0.05	N/A	N/A	0.005
qPCR	N/A	N/A	0.75	0.30	0.005
Standardized qPCR	N/A	N/A	0.75	0.30	0.005
IHC and qPCR	0.07	0.75	0.25	0.53	0.002
Standardized IHC and qPCR	0.34	0.10	0.55	0.97	0.005

¹P-value is for factor's inclusion in stratified Cox model, with adjustment for stratification factors of nodal status and adjuvant chemotherapy.