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. 2013 Oct 31;15(5):R103. doi: 10.1186/bcr3567

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Copyright © 2013 Yau et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FFPE cohort outcome analyzed by recursive partitioning (rpart) using clinical parameters and the five-gene ICS. The rpart analysis selected nodal status and Integrated Cytokine Score (ICS) in a conditional model which best predicts DR outcome. (A)rpart tree, (B) Kaplan-Meier curves of rpart tree branches. Color of curves corresponds to terminal branch color: dark blue = LN-, ICS Low; skyblue = LN- ICS High; red = LN+, (C) Kaplan-Meier curves of the LN-, ICS Low group (dark blue) further stratified by grade (I/II = dashed line, III = dotted line), (D) Kaplan-Meier curves of the LN + rpart group (red) stratified by ICS at an optimal threshold, ICS = -0.4 (Low ICS = dashed line, High ICS = dotted line).