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Change in radiographic measures in big/small change in C1M. Change in radiographic measures (JSN and mTSS) after 52 weeks in patients receiving TCZ with more or less than 35% change in C1M from baseline to 16 weeks. Values are depicted as mean ± 95% CI. Students' t-test was used to test for differences. Significant levels: *: P <0.05. C1M, Type I collagen degraded by MMPs; JSN, joint space narrowing; MMPs, matrix metalloproteinases; mTSS, modified total Sharp score; TCZ, tocilizumab
