Table 3.

Multivariate linear regression analysis of patients in the PBO group, at 24 and 52 weeks.

	Δ24 weeks				Δ52 weeks
JSN	β	P	R2	n	β	P	R2	n
C1M	0.34	0.013	0.04	153	1.38	0.0015	0.11	85
C1M adjusted for CRP	0.74	0.0013	0.06	153	3.91	<0.0001	0.27	85
C1M adjusted for CRP, age, BMI and disease duration	0.69	0.0022	0.11	151	3.60	<0.0001	0.30	83
C1M adjusted for CRP, age, BMI, disease duration and baseline JSN	0.68	0.0029	0.11	151	3.55	<0.0001	0.31	83
mTSS
C1M	1.13	0.0035	0.05	153	3.40	0.0001	0.17	85
C1M adjusted for CRP	1.17	0.07	0.04	153	7.13	<0.0001	0.25	85
C1M adjusted for CRP, age, BMI and disease duration	0.98	0.11	0.14	151	6.12	<0.0001	0.32	83
C1M adjusted for CRP, age, BMI, disease duration and baseline mTSS	0.95	0.13	0.14	151	6.04	<0.0001	0.32	83
ERN
C1M	0.79	0.009	0.038	153	2.01	0.0002	0.15	85
C1M adjusted for CRP	0.43	0.39	0.037	153	3.22	0.0006	0.17	85
C1M adjusted for CRP, age, BMI and disease duration	0.29	0.56	0.12	151	2.52	0.0055	0.25	83
C1M adjusted for CRP, age, BMI, disease duration and baseline ERN	0.26	0.59	0.12	151	2.47	0.0066	0.25	83

BMI, Body mass index; C1M, Type I collagen degraded by MMPs; CRP- C-reactive protein; ERN, erosion score; JSN, joint space narrowing; mTSS, modified total Sharp score. The regression coefficient, β, P-value and R² are given. Data were log-transformed before analysis.