Table 3.
Odds ratios (ORs) and 95% confidence intervals (CIs) for case-case analyses comparing the association with BI-RADS-measured mammographic density by breast cancer risk subtypes
| |
Basal-like versus luminal A |
Triple-negative versus luminal A |
||
|---|---|---|---|---|
|
Model 1
a
|
Model 2
b
|
Model 1 |
Model 2 |
|
| OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| Almost entirely fat |
1.00 (Referent) |
1.05 (0.10, 10.97) |
1.00 (Referent) |
0.33 (0.03, 3.95) |
| Scattered fibroglandular densities |
0.95 (0.09, 9.90) |
1.00 (Referent) |
3.05 (0.25, 36.68) |
1.00 (Referent) |
| Heterogeneously dense |
0.63 (0.06, 6.65) |
0.67 (0.30, 1.49) |
2.62 (0.22, 31.62) |
0.86 (0.44, 1.67) |
| Extremely dense |
1.02 (0.08, 13.50) |
1.08 (0.30, 3.84) |
3.57 (0.26, 49.11) |
1.17 (0.41, 3.35) |
| Ptrend = 0.66c | Ptrend = 0.74 | |||
aModel 1 is adjusted for age, race, body mass index, menopausal status, family history of breast cancer, age at menarche, use of hormone therapy, and parity and age at first full-term pregnancy combined, where BI-RADS category 1 (almost entirely fat) is the referent group; bModel 2 is adjusted for the same variables as Model 1 but BI-RADS category 2 (scattered fibroglandular densities) is the referent group; cP-value for trend test is based on the likelihood ratio test statistic and is two-sided. The same ordinal model was fit to assess the P-value for trend of Model 1 and Model 2. BI-RADS, Breast Imaging Reporting and Data System.