Table 1.
Comparison of pSS and non-pSS patients
|
Overall |
pSS |
No pSS |
P value | |
|---|---|---|---|---|
| n = 181 | n = 77 | n = 104 | ||
| Age (years, mean ± SD) |
56.1 ± 13.0 |
56.3 ± 13.5 |
55.9 ± 12.7 |
0.89 |
| Symptom duration (years, mean ± SD) |
6.4 ± 6.9 |
7.0 ± 7.6 |
6.0 ± 6.3 |
0.48 |
| Female, n (%) |
167 (92.2) |
70 (90.9) |
97 (93.3) |
0.56 |
| Xerophthalmia, n (%) |
156 (86.2) |
70 (90.9) |
86 (82.7) |
0.11 |
| Xerostomia, n (%) |
166 (91.7) |
73 (94.8) |
93 (89.4) |
0.19 |
| Abnormal Schirmer’s test, n (%) |
76 (42.0) |
44 (57.1) |
32 (30.8) |
<0.001 |
| Decreased salivary flow, n (%) |
80 (44.2) |
48 (62.3) |
32 (30.8) |
<0.001 |
| Abnormal salivary gland biopsy, n (%) |
75 (41.4) |
62 (80.5) |
13 (12.5) |
<0.001 |
| Anti-SSA or -SSB positivity, n (%) |
47 (26.0) |
47 (61.0) |
0 (0.0) |
<0.001 |
| AECG criteria, n (%) |
67 (37.0) |
64 (83.1) |
3 (2.9) |
<0.001 |
| Anti-SSA positivity, n (%) |
47 (26.0) |
47 (61.0) |
0 (0.0) |
<0.001 |
| Anti-SSB positivity, n (%) |
25 (13.8) |
25 (32.5) |
0 (0.0) |
<0.001 |
| ANA ≥1:320, n (%) |
105 (58.0) |
62 (80.5) |
43 (41.3) |
<0.001 |
| ANA ≥1:640, n (%) |
73 (40.3) |
54 (70.1) |
19 (18.3) |
<0.001 |
| IgM-RF positivity, n (%) |
56 (30.9) |
35 (45.5) |
21 (20.2) |
<0.001 |
| IgA-RF positivity, n (%) |
37 (20.4) |
32 (41.6) |
5 (4.8) |
<0.001 |
| Gammaglobulins ≥14 g/L, n (%) |
44 (24.3) |
36 (46.8) |
8 (7.7) |
<0.001 |
| IgG ≥14 g/L, n (%) |
47 (26.0) |
38 (49.4) |
9 (8.7) |
<0.001 |
| B-cell ratio ≥5, n (%) |
59 (32.6) |
41 (53.2) |
18 (17.3) |
<0.001 |
| ANA ≥1:320 + IgM-RF, n (%) |
39 (21.5) |
32 (41.6) |
7 (6.7) |
<0.001 |
| ACR criteria serologic item, n (%) | 56 (30.9) | 49 (63.6) | 7 (6.7) | <0.001 |
pSS, primary Sjögren’s syndrome; AECG, American-European Consensus Group; ANA, antinuclear antibodies; Ig, immunoglobulin; RF, rheumatoid factor; ACR criteria serologic item: (anti-SSA/B or (ANA ≥1:320 + IgM-RF)). Xerophthalmia and xerostomia referred to subjective complaints by the patients. Schirmer’s test was considered abnormal if ≤5 mm/5 min and unstimulated salivary flow if ≤0.1 mL/min. Salivary gland biopsies were graded according to Chisholm and Mason. Mann–Whitney and chi-square tests were used as appropriate to compare pSS and non-pSS patients. P <0.05 was considered significant.