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. 2014 Feb 3;16(1):R17. doi: 10.1186/bcr3612

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Copyright © 2014 Wojdacz et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Examples of the overall methylation screening results in cases and controls illustrating a shift in methylation of the locus during carcinogenesis. Standards: 100% methylated (red), 10% methylated in a background of unmethylated template (blue), 1% methylated (yellow) and unmethylated standard (green). Melting peaks were generated by taking the negative derivative (d) of the melting curve data divided by the derivative with respect to time -(d/dT). Each panel displays 20 methylation-sensitive high-resolution melting scans. (A) and (B)BC008699 assay. (C) and (D)SIX6 assay. Scans from control samples are shown in (A) and (C). (B) and (D) show HRM scans of the cancer tissue samples.