Table 2.
Frequencies of DNA methylation in control tissue samples
| Loci ID | Samples a , n | Low methylation b , n (%) | Methylation-negative, n (%) | Methylation-positive c , n (%) |
|---|---|---|---|---|
|
TITF1 |
72 |
47 (65.3) |
25 (34.7) |
0 |
|
HOXB13 |
72 |
13 (18.1) |
59 (81.9) |
0 |
|
NR2E1 |
72 |
6 (8.3) |
66 (91.7) |
0 |
|
HTR1B |
69 |
0 |
69 (100.0) |
0 |
|
HMX2 |
69 |
45d (65.2) |
24 (34.8) |
0 |
|
BC008699 |
72 |
21 (29.2) |
48 (66.7) |
3 (4.2) |
|
SLC38A4 |
62 |
30 (48.4) |
29 (46.8) |
3 (4.8) |
|
FLJ32447 |
70 |
48 (68.6) |
22 (31.4) |
0 |
|
WT1 |
72 |
2 (2.8) |
70 (97.2) |
0 |
|
TMEM132D |
70 |
37 (52.9) |
33 (47.1) |
0 |
|
NKX2-3 |
68 |
68 (100.0) |
0 |
0 |
|
GHSR |
72 |
2 (2.8) |
70 (97.2) |
0 |
|
ONECUT |
71 |
24 (33.8) |
47 (66.2) |
0 |
|
LHX1 |
72 |
0 |
54 (75.0) |
18 (25.0) |
|
SIX6 |
69 |
8 (11.6) |
61 (88.4) |
0 |
|
CA10 |
47 |
24 (51.1) |
23 (48.9) |
0 |
|
CHR |
72 |
72 (100.0) |
0 |
0 |
|
POU4F |
37 |
11 (29.7) |
26 (70.3) |
0 |
| PHOX2B | 72 | 72 (100.0) | 0 | 0 |
aVariable number of samples is reported due to clinical sample limitations. bLow methylation is referred to as methylation similar to the methylation level observed in the 1% methylation standard. cMethylation-positive samples are referred to as samples displaying a HRM profile characteristic for cases. dMethylation level similar to the one observed in the 1% to 10% methylation standard.