Figure 5.

Depletions in the transcriptional landscape of the extracellular milieu during transition from pre- to subclinical Sjögren’s syndrome. (A) Gene sets (GSs) depleted when the mice were 8 weeks of age define marked deceleration of extracellular matrix (ECM) turnover and significantly decreased transcription of genes associated with gap junction formation and neurotransmission. The layout parameters of Figure 4A correspond precisely to the layout parameters of Figure 3. The reference node allows estimation of scaling and direct comparison of Figures 3, 5A, 6A and 7A and Additional file 1: Figure S2A. Mmp, matrix metalloproteinase. (B) Annotation of the Markov cluster algorithm clusters displayed in (A) with their respective leading edge gene clouds. The layout parameters correspond precisely to the layout parameters of Figure 4. The reference node allows estimation of scaling and direct comparison of Figures 4, 5B, 6B and 7B and Additional file 1: Figure S2B.