Figure 7.

Depletions in the transcriptional landscape of the extracellular milieu during transition from subclinical to overt Sjögren’s syndrome. (A) Gene sets (GSs) depleted at 16 weeks of age signify, to a major extent, the partial reversal of enrichments in FAs and cell–cell junction-associated GSs observed at 8 weeks of age. The layout parameters of Figure 6A correspond precisely to the layout parameters of Figure 3. The reference node allows estimation of scaling and direct comparison of Figures 3, 5A, 6A and 7A and Additional file 1: Figure S2A. (B) Annotation of the Markov cluster algorithm clusters displayed in Figure 6A with their respective LE gene clouds. The layout parameters of Figure 6B correspond precisely to the layout parameters of Figure 4. The reference node allows estimation of scaling and direct comparison of Figures 4, 5B, 6B and 7B and Additional file 1: Figure S2B.