Table 2.
Correlation coefficients (ρ) and levels of significance ( P ) between concentration of Cho, PCho, and GPC, and expression of genes contributing in the choline metabolism pathway
| Subgroup | Metabolite | Gene | ρ | P -value |
|---|---|---|---|---|
| All samples (N = 30) |
Cho |
CHPT1 |
0.49 |
0.008 |
| |
|
PLA2G1B |
0.43 |
0.021 |
| |
|
PNPLA6 |
0.41 |
0.028 |
| |
PCho |
CHKA |
0.43 |
0.021 |
| |
|
GDPD5 |
0.38 |
0.041 |
| |
GPC |
CHKA |
0.44 |
0.017 |
| |
|
GDPD5 |
0.56 |
0.002 |
| |
|
LYPLA1 |
-0.40 |
0.030 |
| |
|
PLA2G6 |
0.43 |
0.021 |
| |
|
PLCD1 |
0.37 |
0.045 |
| |
|
PLD3 |
-0.42 |
0.024 |
| |
|
PNPLA7 |
0.39 |
0.035 |
| Basal-like (N = 19) |
Cho |
CHKA |
0.46 |
0.049 |
| |
|
CHPT1 |
0.50 |
0.029 |
| |
|
PLA2G10 |
0.53 |
0.021 |
| |
|
PLA2G6 |
0.61 |
0.006 |
| |
PCho |
CHKA |
0.47 |
0.044 |
| |
|
PLA2G2E |
-0.52 |
0.024 |
| |
|
PLCB4 |
0.51 |
0.027 |
| |
GPC |
CHKA |
0.52 |
0.023 |
| |
|
GDPD5 |
0.73 |
<0.001 |
| |
|
PCYT1B |
0.49 |
0.035 |
| |
|
PLA2G6 |
0.67 |
0.002 |
| |
|
PNPLA7 |
0.52 |
0.021 |
| Luminal B (N = 6) |
Cho |
CHKB |
-0.96 |
0.002 |
| |
|
PLA2G12B |
-0.91 |
0.012 |
| |
|
PLA2G4A |
0.86 |
0.029 |
| |
|
PLCD3 |
-0.86 |
0.027 |
| |
PCho |
PLCB1 |
-0.91 |
0.011 |
| |
|
PLD1 |
0.89 |
0.017 |
| |
GPC |
CHKB |
-0.97 |
0.001 |
| |
|
PLCD3 |
-0.81 |
0.049 |
| SLC22A2 | -0.86 | 0.030 |