Table 4.
BreastMark results for the MammaPrint gene signature for LNN patients using DFS as the survival end point
| Entrez Gene ID | Gene symbol | Hazard ratio | P-value | Sample number | MammaPrint correlation with prognosis |
|---|---|---|---|---|---|
| Good Prognosis | |||||
| 8659 | ALDH4 | 0.92 | 0.42 | 1105 | 0.421 |
| 8817 | FGF18 | 0.86 | 0.16 | 1183 | 0.411 |
| 27113 | BBC3 | 0.76 | 0.03 | 1004 | 0.407 |
| 57593 | KIAA1442 | NA | NA | NA | 0.402 |
| 57758 | CEGP1 | 0.69 | 5.37e-03 | 819 | 0.400 |
| 146923 | RUNDC1 | 0.53 | 2.23e-03 | 387 | 0.390 |
| 8840 | WISP1 | 0.85 | 0.13 | 1183 | 0.384 |
| 2947 | GSTM3 | 0.79 | 0.02 | 1183 | 0.380 |
| 151126 | ZNF533 | 0.84 | 0.39 | 382 | 0.375 |
| 146760 | RTN4RL1 | 0.84 | 0.45 | 281 | 0.374 |
| 10455 | PECI | 0.81 | 0.05 | 1059 | 0.373 |
| 7043 | TGFB3 | 0.83 | 0.09 | 1155 | 0.372 |
| 55351 | HSA250839 | 0.71 | 2.48e-03 | 1109 | 0.368 |
| 10455 | PEC1 | 0.88 | 0.05 | 1059 | 0.366 |
| 58475 | CFFM4 | 0.67 | 0.01 | 510 | 0.364 |
| 163 | AP2B1 | 0.84 | 0.10 | 1155 | 0.363 |
| 79132 | LGP2 | 0.67 | 1.70e-03 | 986 | 0.363 |
| Poor prognosis | |||||
| 55321 | C20orf46 | 1.09 | 0.41 | 1137 | -0.356 |
| 11082 | ESM1 | 1.41 | 1.71e-03 | 1139 | -0.357 |
| 9134 | CCNE2 | 1.74 | 2.74e-06 | 1032 | -0.357 |
| 54583 | EGLN1 | 1.44 | 2.13e-03 | 981 | -0.357 |
| 1058 | CENPA | 1.94 | 1.26e-09 | 1183 | -0.358 |
| 9055 | PRC1 | 1.87 | 1.03e-08 | 1137 | -0.358 |
| 445815 | AKAP2 | 1.01 | 0.95 | 928 | -0.360 |
| 10874 | NMU | 1.51 | 1.12e-04 | 1183 | -0.360 |
| 3488 | IGFBP5 | 1.18 | 0.12 | 1155 | -0.360 |
| 10531 | MP1 | 1.08 | 0.52 | 893 | -0.361 |
| 57110 | LOC57110 | 1.50 | 2.16e-04 | 1109 | -0.361 |
| 3488 | IGFBP5 | 1.19 | 0.12 | 1155 | -0.361 |
| 8577 | TMEFF1 | 1.30 | 0.02 | 1077 | -0.362 |
| 4175 | MCM6 | 1.84 | 1.56e-08 | 1183 | -0.364 |
| 643008 | LOC643008 | NA | NA | NA | -0.365 |
| 83879 | CDCA7 | 1.02 | 0.93 | 387 | -0.365 |
| 5984 | RFC4 | 1.62 | 6.38e-06 | 1183 | -0.366 |
| 23594 | ORC6L | 1.80 | 7.32e-08 | 1137 | -0.366 |
| 6515 | SLC2A3 | 1.12 | 0.29 | 1155 | -0.366 |
| 57211 | DKFZP564D0462 | 0.96 | 0.72 | 1004 | -0.367 |
| 79791 | FBXO31 | 0.85 | 0.13 | 1137 | -0.367 |
| 1633 | DCK | 1.36 | 4.67e-03 | 1155 | -0.368 |
| 51514 | L2DTL | 1.62 | 1.19e-05 | 1109 | -0.369 |
| 1284 | COL4A2 | 1.22 | 0.10 | 1004 | -0.371 |
| 9833 | KIAA0175 | 1.82 | 2.21e-08 | 1183 | -0.371 |
| 92140 | MTDH | 1.32 | 0.01 | 1155 | -0.373 |
| 51377 | UCH37 | 1.19 | 0.11 | 1137 | -0.374 |
| 51560 | RAB6B | 0.98 | 0.84 | 1109 | -0.376 |
| 160897 | GPR180 | 1.24 | 0.31 | 337 | -0.379 |
| 79888 | FLJ12443 | 1.31 | 0.02 | 1004 | -0.381 |
| 8293 | SERF1A | 1.54 | 0.44 | 28 | -0.383 |
| 8476 | PK428 | 1.19 | 0.10 | 1183 | -0.384 |
| 10403 | HEC | 1.34 | 7.04e-03 | 1183 | -0.386 |
| 8833 | GMPS | 1.37 | 3.12e-03 | 1183 | -0.386 |
| 1894 | ECT2 | 1.59 | 1.70e-05 | 1137 | -0.390 |
| 4318 | MMP9 | 1.25 | 0.04 | 1183 | -0.392 |
| 5019 | OXCT | 1.00 | 0.99 | 1183 | -0.392 |
| 2781 | GNAZ | 1.08 | 0.49 | 1155 | -0.396 |
| 2321 | FLT1 | 1.05 | 0.71 | 857 | -0.398 |
| 2131 | EXT1 | 1.25 | 0.04 | 1183 | -0.400 |
| 56942 | DC13 | 1.80 | 4.69e-08 | 1137 | -0.400 |
| 81624 | DIAPH3 | 1.08 | 0.52 | 998 | -0.405 |
| 81624 | DIAPH3 | 1.08 | 0.52 | 998 | -0.409 |
| 169714 | QSOX2 | 1.57 | 0.04 | 343 | -0.415 |
| 286052 | LOC286052 | NA | NA | NA | -0.424 |
| 51203 | LOC51203 | 1.83 | 2.44e-08 | 1137 | -0.425 |
| 81624 | DIAPH3 | 1.08 | 0.52 | 998 | -0.433 |
| 85453 | TSPYL5 | 0.96 | 0.72 | 999 | -0.527 |
DFS, disease-free survival; LNN, lymph node-negative.