Table 1.
Compound | GI50 (µM) | ||
---|---|---|---|
MCF-7 | NCI-H460 | SF-268 | |
Results are given in concentrations that were able to cause 50% of cell growth inhibition (GI50) after a continuous exposure of 48h and represent means of ±SEM of 3 independent experiments performed in duplicate and carry out independently. aResults published elsewhere [3,4]. bResults of one or two experiments performed in duplicate. Doxorubicin was used as positive control, GI50: MCF-7 = 42.8±8.2 nM; NCI-H460 = 94.0±8.7 nM; SF-268 = 93.0±7.0 nM. ND = not determined. | |||
1a | 21.9 ± 0.4 | 20.6 ± 0.9 | 33.4 ± 0.2 |
2a | 50.8 ± 2.2 | 37.9 ± 2.9 | 61.4 ± 5.2 |
3a | 18.4 ± 1.9 | >160 | >160 |
4a | >160 | >160 | >160 |
5a | 88.6 ± 12.9 | >160 | >160 |
6 | >150b | >150b | ND |
7 | >150 | >150b | ND |
8 | >150b | >150b | ND |
9a | >200 | ND | ND |
10 | 55b | >150b | ND |
11 | 88b | ND | ND |