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. 2009 Aug 11;2(2):33–43. doi: 10.3390/ph2020033

Table 1.

Effect of xanthone derivatives 1-11 on the growth of human tumor cell lines.

Compound GI50 (µM)
MCF-7 NCI-H460 SF-268
Results are given in concentrations that were able to cause 50% of cell growth inhibition (GI50) after a continuous exposure of 48h and represent means of ±SEM of 3 independent experiments performed in duplicate and carry out independently. aResults published elsewhere [3,4]. bResults of one or two experiments performed in duplicate. Doxorubicin was used as positive control, GI50: MCF-7 = 42.8±8.2 nM; NCI-H460 = 94.0±8.7 nM; SF-268 = 93.0±7.0 nM. ND = not determined.
1a 21.9 ± 0.4 20.6 ± 0.9 33.4 ± 0.2
2a 50.8 ± 2.2 37.9 ± 2.9 61.4 ± 5.2
3a 18.4 ± 1.9 >160 >160
4a >160 >160 >160
5a 88.6 ± 12.9 >160 >160
6 >150b >150b ND
7 >150 >150b ND
8 >150b >150b ND
9a >200 ND ND
10 55b >150b ND
11 88b ND ND