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. 2014 Mar 6;5(1):147–175. doi: 10.3390/genes5010147

Figure 1.

Figure 1

Schematic model of initiation of DNA synthesis. For sake of clarity, a number of proteins that make the pre-initiation complex (pre-IC) have been grouped in one complex. These include Cdc45, the GINS complex, MCM10, TopBP1, SLD2 and SLD3. A ring-like complex of proteins (in blue in the figure) made of Claspin, Timeless and Tipin make the Fork Protection Complex that tethers the GMC helicase to the DNA polymerases. RNA primers (red waves) are made by the catalytic activity of DNA primase and elongated by the catalytic activity of DNA polymerase α (black arrows linked to red waves).