Table 1.
List of proteins implicated in replication checkpoint activation from yeast to human. Question marks indicate possible homologous genes or those not yet identified homologous.
| Species Gene name | H. sapiens | X. laevis | D. melanogaster | C. elegans | Yeast (S. cerevisiae/S. pombe) |
|---|---|---|---|---|---|
| ATR | ATR | ATR | Mei-41 | atl-1 | Mec1 S.c/Rad3 S.p. |
| ATRIP | ATRIP | ATRIP | mus 304 | ATRIP | Ddc2/ATRIP |
| TopBP1 | TopBP1 | TopBP1 | mus 101 | mus 101 | Dbp11/Cut5 |
| Rad9 | Rad9 | Rad9 | Rad9 | Hrp-9 | Ddc1/Rad9 |
| Rad1 | Rad1 | Rad1 | Rad1/Dmel | mrt-2 | Rad17 |
| Hus1 | Hus1 | Hus1 | hus1 | hus-1 | Mec3/Hus1 |
| Rad17 | Rad17 | Rad17 | Rad17 | hrp-17 | Rad24/Rad17 |
| Claspin | Claspin | Claspin | Claspin | F25H5.5 | Mrc1/Mrc1 |
| Timeless | Timl | Tim 1 | Tim | tim-1 | Tof1/Swi1 |
| Tipin | Tipin | Tipin | Timeout | ? | Csm3/Swi3 |
| CHK1 | CHK1 | CHK1 | grp1/DChk1 | CHK1 | Chk1/Rad27 |
| CDC25A | CDC25A | CDC25A | String | CDC-25 | CDC25 |