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. 2013 Nov 18;15(6):R192. doi: 10.1186/ar4382

Figure 5.

Figure 5

Effect of PEA-LUT combination therapy on cytokines, chemokine expression, and neutrophil infiltration. A substantial increase in the expression of MIP-1α (A), MIP-2 (B), IL-1β (C), IL-6 (D), TNF-α (E), and MPO activity (F) was found in CIA-control mice 35 days after CII immunization. CIA-PEA-treated mice demonstrated a significant reduction in the expression of MIP-1α (A), MIP-2 (B), IL-1β (C), IL-6 (D), TNF-α (E), and MPO activity (F). CIA-LUT-treated mice did not significantly reduce the expression of MIP-1α (A), MIP-2 (B), IL-1β (C), IL-6 (D), TNF-α (E), and MPO activity (F). The combination therapy with PEA-LUT significantly reduced the expression of MIP-1α (A), MIP-2 (B), IL-1β (C), IL-6 (D), TNF-α (E), and MPO activity (F). Values are shown as mean ± SEM of 20 animals for each group. *P < 0.01 versus Sham-control. °P < 0.01 versus CIA-control. #P < 0.01 versus CIA-PEA. §P < 0.01 versus CIA-LUT.