Table 3.
Top 10 molecules which demonstrated the highest upregulation and downregulation in treated discs.
| Gene symbol | Gene description | Expression levels |
|---|---|---|
| ORM1/ORM2 | Orosomucoid 1 | 31.714 |
| CCL20 | Chemokine (C-C motif) ligand 20 | 24.260 |
| TFPI2 | Tissue factor pathway inhibitor 2 | 23.074 |
| IL6 | Interleukin 6 | 21.493 |
| MMP3 | Matrix metallopeptidase 3 | 21.267 |
| CYP7B1 | Cytochrome P450, family 7, subfamily b, | 20.756 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | 19.843 |
| LCN2 | Lipocalin 2 | 18.146 |
| PTGES | Prostaglandin E | 15.958 |
| INHBA | Inhibin beta-A | 15.593 |
| KRT19 | Keratin 19 | -26.767 |
| ASPN | Asporin | -17.890 |
| KRT8 | Keratin 8 | -14.161 |
| IBSP | Integrin-binding sialoprotein | -12.914 |
| COL1A2 | Collagen, type I, alpha 2 | -10.794 |
| Lyz1/Lyz2 | Lysozyme | -8.718 |
| H19 | Imprinted maternally expressed transcript | -8.222 |
| COL1A1 | Collagen, type I, alpha 1 | -7.395 |
| IGF1 | Insulin-like growth factor 1 | -6.578 |
| CRYAB | Crystallin, alpha B | -6.199 |