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. 2013 Oct 4;15(5):R146. doi: 10.1186/ar4329

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Copyright © 2013 Liao et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Marginal effect of RO9021 in the JAK–STAT pathway. Human peripheral blood mononuclear cells were pretreated with RO9021 or the janus kinase (JAK) inhibitor tofacitinib and then stimulated with IL-2 to induce STAT5 phosphorylation in CD3⁺ T cells (A) or IFNγ to induce STAT1 phosphorylation in CD14⁺ monocytes/macrophages (B). Left panels, representative overlaid histograms of flow cytometric analysis. Filled gray, unstimulated; filled red, stimulated with IL-2 or IFNγ. Blue line, treatment with 1 μM RO9021; green line, treatment with 1 μM JAK inhibitor (tofacitinib). Right panels: concentration-dependent inhibition curves of RO9021 (dots) and tofacitinib (squares).